Tuesday, 25 October 2016

Surface modification of starch based biomaterials by oxygen plasma or UV-irradiation

Published Date

Article
DOI: 10.1007/s10856-009-3831-0


Cite this article as: 
Pashkuleva, I., Marques, A.P., Vaz, F. et al. J Mater Sci: Mater Med (2010) 21: 21. doi:10.1007/s10856-009-3831-0


Author 

  • Iva Pashkuleva
  • Email author
  • Alexandra P. Marques
  • Filipe Vaz
  • Rui L. Reis

  • Abstract

    Radiation is widely used in biomaterials science for surface modification and sterilization. Herein, we describe the use of plasma and UV-irradiation to improve the biocompatibility of different starch-based blends in terms of cell adhesion and proliferation. Physical and chemical changes, introduced by the used methods, were evaluated by complementary techniques for surface analysis such as scanning electron microscopy, atomic force microscopy, contact angle analysis and X-ray photoelectron spectroscopy. The effect of the changed surface properties on the adhesion of osteoblast-like cells was studied by a direct contact assay. Generally, both treatments resulted in higher number of cells adhered to the modified surfaces. The importance of the improved biocompatibility resulting from the irradiation methods is further supported by the knowledge that both UV and plasma treatments can be used as cost-effective methods for sterilization of biomedical materials and devices.

    Abbreviations

    SEVA-C
    Blend of starch with poly[ethylene-co-(vinyl alcohol)] copolymer (50/50 wt%)
    SCA
    Blend of starch with cellulose acetate (50/50 wt.%)
    SPCL
    Blend of starch with poly(ε-caprolactone) (70/30 wt.%)
    RT
    Room temperature
    XPS
    X-ray photoelectron spectroscopy
    FTIR
    Fourier transform infrared spectroscopy
    SEM
    Scanning electron microscope
    AFM
    Atomic force microscopy
    DMEM
    Dulbecco’s modified Eagle’s medium
    FBS
    Fetal bovine serum
    PBS
    Phosphate buffered saline solution

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