Keratin/Polyvinyl Alcohol Blend Films Cross-Linked by Dialdehyde Starch and Their Potential Application for Drug Release

Title
Keratin/Polyvinyl Alcohol Blend Films Cross-Linked by Dialdehyde Starch and Their Potential Application for Drug Release

Author 
Yao Dou; Buning Zhang; Ming He; Guoqiang Yin; Yingde Cui; Irina N. Savina (2015)

Publisher: Multidisciplinary Digital Publishing Institute

Journal: Polymers

Languages: English

Types: Article

Subjects:  dialdehyde starch, Science (General), degradable film, Q, feather keratin, PVA, eco-friendly material, Q1-390, Science

Identifiers:doi:10.3390/polym7030580

Abstract 

Feather keratin (FK) extracted from feathers represents a valuable source of biodegradable and biocompatible polymer. The aim of this study was the development and characterization of blended films based on FK and polyvinyl alcohol (PVA) cross-linked by dialdehyde starch (DAS) for a potential drug release application. The compatibility of FK/PVA was improved when cross-linked by DAS: the relative crystallinity of the PVA/FK film slightly decreased, and the enthalpy value for the melting peak decreased by about 50% for the cross-linked films. The total soluble mass of all blend films in water was below 35% at 37 °C, indicating a good stability of the films in water. The results of the Rhodamine B dye (as a model drug) release tests showed that the release rates decreased with increasing DAS content. DAS-induced cross-linking improves several important properties of the FK/PVA films, such as the compactness, the compatibility, and the stability in water. These improvements offer the potential to expand the application of FK films in the biomaterial field.

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