pH-Sensitive drug delivery system based on modified dextrin coated mesoporous silica nanoparticles

Published Date
April 2016, Vol.85:596–603, doi:10.1016/j.ijbiomac.2016.01.038

Title 
pH-Sensitive drug delivery system based on modified dextrin coated mesoporous silica nanoparticles

Author 

Hongyu Chen ^a

Diwei Zheng ^a

Jia Liu ^b

Ying Kuang ^c

Qilin Li ^b

Min Zhang ^a

Haifeng Ye ^a

Hongyang Qin ^a

Yanglin Xu ^d

Cao Li ^a,,

Bingbing Jiang ^a,,

• aHubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Green Preparation and Application of Functional Materials of Ministry of Education, Hubei University, Wuhan, Hubei 430062, PR China
• bCenter for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China
• cDepartment of Food Science and Technology, School of Bio-engineering, Hubei University of Technology, Wuhan, Hubei 430068, PR China
• dHubei Research Institute of Products Quality Supervision and Inspection, Wuhan, Hubei 430061, PR China

Received 16 November 2015. Revised 6 January 2016. Accepted 11 January 2016. Available online 14 January 2016.

Abstract

In this work, a novel pH-sensitive drug delivery system based on modified dextrin coated mesoporous silica nanoparticles (MSNs), DOX@MSN-DDA-CL, are prepared. The dextrin grafting on the surface of MSNs is oxidized by KIO₄ to obtain dextrin dialdehyde, which is then cross-linked by tetraethylenepentamine through a pH-sensitive Schiff’s base. Under physiological conditions, the cross-linked dextrin dialdehyde blocks the pores to prevent premature release of model drug doxorubicin hydrochloride (DOX). In the weak acidic environment, pH 6.0 in this work, the Schiff’s base can be hydrolyzed and released the drug. The in vitro drug release studies at different pHs prove the pH-sensitivity of DOX@MSN-DDA-CL. The cytotoxicity and cell internalization behavior are also investigated in detail. In vivo tissue distribution and pharmacokinetics with a H22-bearing mouse animal mode are also studied, prove that DOX@MSN-DDA-CL has a longer retention time than that of pure DOX and can accumulate in tumor region via enhanced permeation and retention and nanomaterials-induced endothelial cell leakiness effects. In conclusion, the pH-sensitive modified dextrin/MSNs complex drug delivery system has a great potential for cancer therapy.

Keywords

Modified dextrin

Mesoporous silica nanoparticles

Controlled release

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