Preparation and characterization of protein resistant zwitterionic starches: The effect of substitution degrees (pages 920–929)

Published Date
First published: 22 June 2015

DOI: 10.1002/star.201500083

Author
Jinmei Wang, Junjie Li, Huaming Yang, Chuanshun Zhu, Jun Yang, Fanglian Yao

Title

Preparation and characterization of protein resistant zwitterionic starches: The effect of substitution degrees

Abstract

Zwitterionic polymers are known to possess excellent protein resistance due to high hydration capacity of their zwitterionic moieties. In this study, polysaccharide-based zwitterionic polymers 3-dimethyl(propyl) ammonium propanesulfonate starches (Z-starches) with different degrees of substitution of the zwitterionic moieties (DSZM) were synthesized successfully. The value of DSZM can be controlled exactly in the range of 0–0.46. The cytotoxicity of Z-starches with different DSZM was evaluated by an MTT assay, and the Z-starch with DSZM of 0.26 promoted cell proliferation when the concentration of this polymer solution was 1–25 mg/mL. The protein resistance and cell adhesion of Z-starch hydrogels were evaluated, and the amount of protein adsorption or cell adhesion on Z-starch hydrogels was decreased as the DSZMincreased. The preliminary protein resistance and cell adhesion tests suggest that the Z-starches have potential applications in drug delivery carriers and coatings of implanted sensors where protein resistance is needed.

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http://onlinelibrary.wiley.com/doi/10.1002/star.201500083/full