Starch

Published Date
1996, Vol.24:523–577, doi:10.1016/S0099-5428(08)60702-9

Title 
Starch

• Author 

• Ann W. Newman
• Ronald L. Mueller
• Imre M. Vitez
• Chris C. Kiesnowski
• David E. Bugay
• W. Paul Findlay
• Chris Rodriguez

• Bristol-Myers Squibb Pharmaceutical Research Institute One Squibb Drive New Brunswick, NJ 08903

Available online 16 April 2008.

Publisher Summary

Starch is a polymeric material with a molecular formula of (C₆H₁₀O₅)_n, where n ranges from 300 to 1000. Common starches contain two types of D-glucopyranose polymers: amylose and amylopectin. Starch can be found in various parts of plants, and several extraction methods are used to isolate the material. The most common type of starch used in the pharmaceutical industry is corn, although studies with other forms have also been performed. Starch is widely used in the pharmaceutical industry because it is readily available, inexpensive, white, and inert. A function of starch can depend on the way it is incorporated into a formulation. Starch can function as a disintegrant when it is added in a dry state prior to adding a lubricant. It may exhibit both binding and disintegrant properties when it is incorporated either as a paste or as a dry material before granulation with other agents.

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