Investigation and optimization of formulation factors of a hydrogel network based on kappa carrageenan–pregelatinized starch blend using an experimental design

Published Date

20 September 2014, Vol.458:117–125, doi:10.1016/j.colsurfa.2014.01.007

Formula VII: How Does Your Formulation Work?

Title 

Investigation and optimization of formulation factors of a hydrogel network based on kappa carrageenan–pregelatinized starch blend using an experimental design

• Author 

• Sonia Lefnaoui ^,
• Nadji Moulai-Mostefa

• Materials and Environmental Laboratory, Faculty of Sciences and Technology, University of Medea, Ain D’Heb, 2001 Medea, Algeria

Received 2 August 2013. Revised 31 October 2013. Accepted 7 January 2014. Available online 19 January 2014.

Highlights

• •
  A buccal gel for miconazole delivery was developed using κ-carrageenan–pregelatinized starch blend.
• •
  A Box–Behnken design was employed to optimize and investigate the factor effects on the gel properties.
• •
  The optimal formulation was characterized in terms of swelling, bioadhesion and release kinetics.
• •
  The most formulations showed extended release profiles of miconazole over 2 h.
• •
  The properties of the optimized gel were compared with a commercial one based on pregelatinized starch.

Abstract

In the present work we evaluate the results of a combination of two hydrophilic polymers such as kappa carrageenan (κ-Carr) and pregelatinized starch (PGS) in the improvement of the properties of a gel blend containing miconazole. A design of experiments and in particular a Box–Behnken design was applied for the optimization and assessment of the effects of three independent factors (amounts of κ-Carr, glycerol and polysorbate 80) on the bioadhesive properties and drug release kinetics of kappa carrageenan–pregelatinized starch blend. The in-vitro release study revealed that the most formulations showed extended release profiles of miconazole over 2 h. The majority of the matrices that contained 0.3% of κ-Carr eroded prematurely. From the obtained results it was noticed that the gel matrices released drug by diffusion. It was also shown that the addition of κ-Carr to PGS-based gel improves its bioadhesive characteristics and the extended drug release. The optimized gel deduced from the experimental design was characterized and its properties such as swelling, bioadhesion and release kinetics were evaluated.

Graphical abstract

Keywords

• Bioadhesive hydrogel
• Pregelatinized starch
• Kappa carrageenan
• Drug release
• Optimization
• Design of experiments

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• ⁎ 
  Corresponding author. Fax: +213 25 59 45 40.

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http://www.sciencedirect.com/science/article/pii/S0927775714000399