Surface modification of starch based biomaterials by oxygen plasma or UV-irradiation

Published Date

Article

First Online: 

29 July 2009

DOI: 10.1007/s10856-009-3831-0

Cite this article as: 

Pashkuleva, I., Marques, A.P., Vaz, F. et al. J Mater Sci: Mater Med (2010) 21: 21. doi:10.1007/s10856-009-3831-0

Author 

Iva Pashkuleva

Email author

Alexandra P. Marques

Filipe Vaz

Rui L. Reis

Abstract

Radiation is widely used in biomaterials science for surface modification and sterilization. Herein, we describe the use of plasma and UV-irradiation to improve the biocompatibility of different starch-based blends in terms of cell adhesion and proliferation. Physical and chemical changes, introduced by the used methods, were evaluated by complementary techniques for surface analysis such as scanning electron microscopy, atomic force microscopy, contact angle analysis and X-ray photoelectron spectroscopy. The effect of the changed surface properties on the adhesion of osteoblast-like cells was studied by a direct contact assay. Generally, both treatments resulted in higher number of cells adhered to the modified surfaces. The importance of the improved biocompatibility resulting from the irradiation methods is further supported by the knowledge that both UV and plasma treatments can be used as cost-effective methods for sterilization of biomedical materials and devices.

Abbreviations

SEVA-C

Blend of starch with poly[ethylene-co-(vinyl alcohol)] copolymer (50/50 wt%)

SCA

Blend of starch with cellulose acetate (50/50 wt.%)

SPCL

Blend of starch with poly(ε-caprolactone) (70/30 wt.%)

RT

Room temperature

XPS

X-ray photoelectron spectroscopy

FTIR

Fourier transform infrared spectroscopy

SEM

Scanning electron microscope

AFM

Atomic force microscopy

DMEM

Dulbecco’s modified Eagle’s medium

FBS

Fetal bovine serum

PBS

Phosphate buffered saline solution

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