Advances in biomedical and pharmaceutical applications of functional bacterial cellulose-based nanocomposites

Published Date

5 October 2016, Vol.150:330–352, doi:10.1016/j.carbpol.2016.05.029

Review

Title 

Advances in biomedical and pharmaceutical applications of functional bacterial cellulose-based nanocomposites

• Author 

• Hanif Ullah ^a,c
• Fazli Wahid ^b
• Hélder A. Santos ^c,,
• Taous Khan ^a,,

• aDepartment of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
• bBiotechnology Program, Department of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
• cDivision of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland

Received 22 January 2016. Revised 25 April 2016. Accepted 11 May 2016. Available online 14 May 2016.

Highlights

• •
  Summarizes various biomedical applications of BC-based nanocomposites.
• •
  Highlights recent advances of these nanocomposites in drug delivery.
• •
  Describes the potential of BC-nanocomposites for extensive uses in biosensors, bioanalyses, cell and enzymes immobilization, and stem cell therapy.
• •
  Enlightens some future prospects of BC-based nanocomposites in biomedical and pharmaceutical field.

Abstract

Bacterial cellulose (BC) synthesized by certain species of bacteria, is a fascinating biopolymer with unique physical and mechanical properties. BC’s applications range from traditional dessert, gelling, stabilizing and thickening agent in the food industry to advanced high-tech applications, such as immobilization of enzymes, bacteria and fungi, tissue engineering, heart valve prosthesis, artificial blood vessels, bone, cartilage, cornea and skin, and dental root treatment. Various BC-composites have been designed and investigated in order to enhance its biological applicability. This review focuses on the application of BC-based composites for microbial control, wound dressing, cardiovascular, ophthalmic, skeletal, and endodontics systems. Moreover, applications in controlled drug delivery, biosensors/bioanalysis, immobilization of enzymes and cells, stem cell therapy and skin tissue repair are also highlighted. This review will provide new insights for academia and industry to further assess the BC-based composites in terms of practical applications and future commercialization for biomedical and pharmaceutical purposes.

Keywords

• Bacterial cellulose
• Bioengineering
• Biomedical application
• Composites
• Nanocellulose

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• ⁎ 
  Corresponding authors.

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