Published Date
September 1971, Vol.60(9):1325–1332, doi:10.1002/jps.2600600907
For further details log on website :
http://www.sciencedirect.com/science/article/pii/S0964830516300889
September 1971, Vol.60(9):1325–1332, doi:10.1002/jps.2600600907
RESEARCH ARTICLES
Author
Received 12 November 1970. Accepted 24 May 1971. Available online 22 January 2016.
Abstract
Two full factorial experiments were designed. The first one had three disintegrants (corn starch, cation-exchange resin, and waxy maise starch) at four different concentrations (0, 5, 10, and 15%), and three levels of compression pressure (1000, 3000, and 6000 psig.) with aspirin. The second experiment had four different medicaments (aspirin, MgO, Mg trisilicate, and salicylamide), three levels of pressure, and corn starch at the four concentration levels. Mean pore diameter, porosity, and disintegration time were the measured parameters. Mean pore diameters were measured in an air permeability apparatus and calculated from: 
Dried corn starch with 2% moisture was compared to regular corn starch containing 11% moisture. The effect of colloidal silicon dioxide was also studied. Broad generalities as to the effect of the variables on the measured parameters could not be made because of the complexities and interactions of the variables; i.e., disintegrant concentration effect on mean pore diameter varied with the medicament used, the pressure level, and even the specific disintegrant. Neither the effect on mean pore diameter nor porosity was found to be the mechanism of action of starch and other disintegrants in disintegrating tablets under the conditions of these experiments.
Dried corn starch with 2% moisture was compared to regular corn starch containing 11% moisture. The effect of colloidal silicon dioxide was also studied. Broad generalities as to the effect of the variables on the measured parameters could not be made because of the complexities and interactions of the variables; i.e., disintegrant concentration effect on mean pore diameter varied with the medicament used, the pressure level, and even the specific disintegrant. Neither the effect on mean pore diameter nor porosity was found to be the mechanism of action of starch and other disintegrants in disintegrating tablets under the conditions of these experiments.Keyphrases
- Starch—mechanism as tablet disintegrant
- Tablet disintegration—mean pore diameter, porosity, disintegration time parameters
- Disintegration, tablets—medicaments, disintegrant effects on mean pore diameter and porosity
For further details log on website :
http://www.sciencedirect.com/science/article/pii/S0964830516300889
No comments:
Post a Comment