Fabrication and magnetic testing of a poly-L-lactide biocomposite incorporating magnetite nanoparticles

Author

Li-Kuo Shen1, 2 / Kang-Hsin Fan3 / Ting-Lin Wu4 / Haw-Ming Huang4 / Ting-Kai Leung5 / Chi-Jen Chen1 / Wei-Jen Chang6

1Department of Radiology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan

2Department of Medical Imaging and Radiological Technology, Yuanpei University, Hsinchu, Taiwan

3Dental Department, En Chu Kong Hospital, New Taipei City, Taiwan

4Graduate Institute of Biomedical Materials and Tissue Engineering, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan

5Department of Diagnostic Radiology, Taipei Municipal Wanfang Hospital, Taipei Medical University, Taipei, Taiwan

6School of Dentistry, Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, 11031, 250 Wu-Hsing Street, Taipei, Taiwan; and Dental Department, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan

Corresponding author: Wei-Jen Chang, School of Dentistry, Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, 11031, 250 Wu-Hsing Street, Taipei, Taiwan; and Dental Department, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan, e-mail:  (email)

aThese authors contributed equally to this work.

Citation Information: Journal of Polymer Engineering. Volume 34, Issue 3, Pages 231–235, ISSN (Online) 2191-0340, ISSN (Print) 0334-6447, DOI: https://doi.org/10.1515/polyeng-2013-0207, November 2013

Publication History

Received:

2013-08-29

Accepted:

2013-10-14

Published Online:

2013-11-21

Abstract

Polylactic acid (PLA)-based composite has been widely used in tissue engineering. To modify the material’s properties, inorganic substances have been used to form nanoparticle-PLA composites. The aim of this study is to develop a novel magnetic biodegradable composite. Nanoscale magnetite (Fe3O4) was incorporated into a poly-L-lactide (PLLA) matrix with proportions of 0%, 5%, 10%, and 15% (w/w). Injection molding was carried out to produce the nano-magnetite-PLLA composite samples. X-ray diffraction (XRD), differential scanning calorimetry (DSC), superconducting quantum device (SQUID), and three-point bending were performed to test the physical properties of the magnetite-PLLA composite. The results showed that the magnetite-PLLA composite exhibited typical ferromagnetic hysteresis loops. The addition of nanoscale magnetite significantly increased the magnetic flux density of the PLLA composite. These results suggest that the magnetite-PLLA composite has the potential to be used for future applications in tissue engineering.

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