Anti-hypoglycemic effect of aqueous leaf extract of Siamese neem tree (Azadirachta indica) in Plasmodium berghei infected mice

 International Food Research Journal, Volume 23, Issue 2, 2016, pp. 885-888

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Anti-hypoglycemic effect of aqueous leaf extract of Siamese neem tree (Azadirachta indica) in Plasmodium berghei infected mice

 Somsak V. * 1, Srichairatanakool S. 2, Uthaipibull C. 3

Abstract : Hypoglycemia has been reported during malaria infection in blood stage, and can cause of death in malaria endemic countries. Hence, in this study was aimed to evaluate anti-hypoglycemic effect of Siamese neem tree extract in P. berghei infected mice. The aqueous leaf extract of Siamese neem tree was freshly prepared and used for orally treatment. Groups of ICR mice were infected intraperitoneally with 6x106 infected erythrocytes of P. berghei ANKA, and subsequently given with the extract twice a day for 4 consecutive days. Blood glucose levels were then measured. Normal and untreated mice were used as healthy and disease controls, respectively. The results showed that hypoglycemia was developed during P. berghei ANKA infection in mice as indicated by decreasing of blood glucose level. However, blood glucose level in the extract treated mice was similar to normal group. It can be summarized that aqueous leaf extract of Siamese neem tree exhibited anti-hypoglycemic effect against P. berghei ANKA infected mice.

Keywords : Anti-hypoglycemia,Azadirachta indica,Plasmodium berghei,Siamese neem tree

Subject Area : Food Science

 Reference (13)

1. Hypoglycemia and hyperinsulinemia in rodent models of severe malaria infection

Elased K., Playfair J.H.

Infection and Immunity(1994), Volume 62, Issue 11, pp. 5157-5160

2. Malaria, blood glucose, and the role of tumour necrosis factor (TNF) in mice

Elased K.M., Taverne J., Playfair J.H.

Clinical and Experimental Immunology(1996), Volume 105, Issue 3, pp. 443-449

3. Raised plasma insulin level and homeostasis model assessment (HOMA) score in cerebral malaria: evidence for insulin resistance and marker of virulence

Eltahir E.M., El Ghazali G., A-Elgadir T.M., A-Elbasit I.E., Elbashir M.I., Giha H.A.

Acta Biochimica Polonica(2010), Volume 57, Issue 4, pp. 513-520

4. Plasmodium berghei: gluconeogenesis in the infected mouse liver studied by 13C nuclear magnetic resonance

Geoffrion Y., Butler K., Pass M., Smith I.C., Deslauriers R.

Experimental Parasitology(1985), Volume 59, Issue 3, pp. 364-374

doi.10.1016/0020-708X(85)90046-8

5. A review of malaria transmission dynamics in forest ecosystems

Kar N.P., Kumar A., Singh O.P., Carlton J.M., Nanda N.

Parasit Vectors(2014), Volume 7, Issue 1, pp. 265-277

doi.10.1186/1756-3305-7-265

6. Limonoids and flavonoids from the flowers of Azadirachta indica var. siamensis, and their melanogenesis-inhibitory and cytotoxic activities

Kitdamrongtham W., Ishii K., Ebina K., Zhang J., Ukiya M., Koike K., Akazawa H., Manosroi A., Manosroi J., Akihisa T.

Chemistry and Biodiversity(2014), Volume 11, Issue 1, pp. 73-84

doi.10.1002/cbdv.201300266

7. Point-of-admission hypoglycaemia among under-five Nigerian children with Plasmodium falciparum malaria: prevalence and risk factors

Onyiriuka A.N., Peter O.O., Onyiriuka L.C., Awaebe P.O., Onyiriuka F.U.

Medical Journal of the Islamic Republic of Iran(2012), Volume 26, Issue 2, pp. 78-84

8. The chemotherapy of rodent malaria, XXII. The value of drug-resistant strains of P. berghei in screening for blood schizontocidal activity

Peters W.

Annals of Tropical Medicine and Parasitology(1975), Volume 69, Issue 2, pp. 155-171

doi.10.1080/00034983.1975.11686997

9. Antioxidant activity of Siamese neem tree (VP1209)

Sithisarn P., Supabphol R., Gritsanapan W.

Journal of Ethnopharmacology(2005), Volume 99, Issue 1, pp. 109-112

doi.10.1016/j.jep.2005.02.008

10. Comparison of free radical scavenging activity of Siamese neem tree (Azadirachta indica A. Juss var. siamensis Valeton) leaf extracts prepared by different methods of extraction

Sithisarn P., Supabphol R., Gritsanapan W.

Medical Principles and Practice(2006), Volume 15, Issue 3, pp. 219-222

doi.10.1159/000092185

11. Studies with the Plasmodium falciparum hexokinase reveal that PfHT limits the rate of glucose entry into glycolysis

Tjhin E.T., Staines H.M., van Schalkwyk D.A., Krishna S., Saliba K.J.

FEBS Letters(2013), Volume 587, Issue 19, pp. 3182-3187

doi.10.1016/j.febslet.2013.07.052

12. FFAs are not involved in regulation of gluconeogenesis and glycogenolysis in adults with uncomplicated P. falciparum malaria

van Thien H., Weverling G.J., Ackermans M.T., Canh Hung N., Endert E., Kager P.A., Sauerwein H.P.

American Journal of Physiology-Endocrinology and Metabolism(2004), Volume 287, Issue 4 50-4, pp. E609-E615

doi.10.1152/ajpendo.00026.2004

13. Hexose permeation pathways in Plasmodium falciparum-infected erythrocytes

Woodrow C.J., Burchmore R.J., Krishna S.

Proceedings of the National Academy of Science(2000), Volume 97, Issue 18, pp. 9931-9936

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