Anti-ulcer activity of Hibiscus cannabinus and Hibiscus sabdariffa seeds in ulcer-induced rats

 International Food Research Journal, Volume 23, Issue 3, 2016, pp. 1164-1172

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Anti-ulcer activity of Hibiscus cannabinus and Hibiscus sabdariffa seeds in ulcer-induced rats

 Nyam K.L. * 1, Tang J.L.K. 1, Long K. 2

Abstract : The aim of this research is to determine the antiulcer properties and percentage protection of Hibiscus cannabinus and Hibiscus sabdariffa seed samples towards ulcer-induced Sprague dawley rats. Rats were divided into six groups each for each ulceration method and fed with distilled water, Omeprazole, H. cannabinus seed oil (HCSO), H. cannabinus seed extract (HCSE), H. sabdariffa seed oil (HSSO) and H. sabdariffa seed extract (HSSE), respectively via oral administration. Among the two plants tested, H. cannabinus showed the best protection percentage towards ethanol, non-steroidal anti-inflammatory drugs (NSAIDs) and cold restrain stress induced ulcers. H. cannabinus seed extract (HSSE) exhibited an exceptionally high ulcer protection of 74.98 ± 0.78% against NSAIDs induced ulcer. The gastric lesions were controlled primarily by both mucosal protection and acid inhibition. In conclusion, addition of these seeds to the daily diet may reduce free radical activity in the body and reduce the risk of developing peptic ulcer disease.

Keywords : (NSAID)-induced ulcer,Cold-restraint stress induced,Drug,Ethanol-induced ulcer,Gastric juice,Non-steroidal antiinflammatory,Ulcer,Ulcer index

Subject Area : Food Science

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