Chemical-Induced Naive Pluripotency

Published Date

19 May 2016, Vol.23(5):532–534, doi:10.1016/j.chembiol.2016.05.002

Preview

Title 

Chemical-Induced Naive Pluripotency

• Author 

• Angela J. Russell ^1,2,,
• Laurence Silpa ¹

• 1Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK
• 2Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK

Available online 19 May 2016.

The capacity to harness the properties of pluripotent stem cells has a wide-reaching impact on regenerative medicine, drug discovery, and also basic science. Two recent publications by Ursu et al. and Illich et al. demonstrate that inhibition of a CK1 isoform efficiently induces naive pluripotency in epiblast stem cells.

---

Figure 1.

• ∗ 
  Corresponding author

For further details log on website :
http://www.sciencedirect.com/science/article/pii/S2451945616301337