Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol

Published Date
September 2009, Vol.89(3):135–139, doi:10.1016/j.prostaglandins.2009.04.009
New Intercellular Lipid Mediators and Their Receptors

Mini review

• Kumiko Makide ^a
 
• Hajime Kitamura ^a
 
• Yusuke Sato ^a
 
• Michiyo Okutani ^a
 
• Junken Aoki ^a,b,,

• aGraduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan
• bPRESTO, Japan Science and Technology Corporation, Japan

Received 18 April 2009. Accepted 29 April 2009. Available online 7 May 2009. 

Abstract 

It is now widely accepted that lysophospholipids (LPLs), a product of the phospholipase A reaction, function as mediators through G-protein-coupled receptors. Notably, recent studies of lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have revealed their essential roles in vivo. On the other hand, other LPLs such as lysophosphatidylserine (LPS), lysophosphatidylthreonine (LPT), lysophosphatidylethanolamine (LPE), lysophosphatidylinositol (LPI) and lysophosphatidylglycerol (LPG) have been reported to show lipid mediator-like responses both in vivo (LPS and LPT) and in vitro (LPS, LPT, LPE and LPG), while very little is known about their receptor, synthetic enzyme and patho-physiological roles. In this review, we summarize the actions of these LPLs as lipid mediators including LPS, LPT, LPE and LPG.

Keywords

Lysophospholipids

Receptor

Enzyme

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Fig. 1.

 Table 1

Table 1.

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  Corresponding author at: Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. Tel.: +81 22 795 6860; fax: +81 22 795 6859.

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